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Our Team

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Prof. Mario Strazzabosco, MD PhD
e-mail: mario.strazzabosco@yale.edu

Scientific Director of the CeLiveR project and of the Center for Liver Studies at Ospedali Riuniti di Bergamo, Dr. Strazzabosco is also Professor of Gastroenterology at the University of Milano-Bicocca and an adjunct full Professor of Medicine at the Yale University School of Medicine, where, prior to entering the faculty of Milano-Bicocca was Professor of Medicine and Director of Transplant Hepatology. Currently, at Yale, Dr. Strazzabosco is Program Director of Hepatobiliary Cancer and also Deputy Director of the Yale Liver Center. His areas of interest focus on the cell biology of biliary epithelium and biliary pathophysiology of the biliary tree. The laboratory of Prof. Strazzabosco was among the first to isolate and characterize biliary cells, to reveal their physiological properties and their adaptive responses to liver damage.
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Dr. Luca Fabris, MD PhD
e-mail: luca.fabris@unipd.it

Luca Fabris graduated in Medicine with specialization in Internal Medicine at the University of Padua. He obtained the PhD degree in Clinical Physiopathology at the University of Milan, completing their training at major scientific international hepatology laboratories such as the Liver Center of University-Hospital in Birmingham (UK), the Department of Morphology University of Leuven (Belgium) and the Liver Center at Yale (New Haven, USA), with which Dr. Fabris maintains ongoing established collaborative projects on hepatic fibrogenesi related to genetic cholangiopaties. He is currently Associate Professor at the Department of Molecular Medicine, University of Padua and the Consultant for the UOC of Gastroenterology at the San Gerardo Hospital (Monza) where he also conducts research at the ICDH on the molecular pathogenesis of malformative cholangiopaties and of colangiocarcinoma. He is a member of several scientific societies on the hepatology and digestive diseases field, and is referee, among others, of Journal of Hepatology, Hepatology, and Gastroenterology.

Prof. Luciano G. De Carlis

Prof. De Carlis is General Director of the HPB and Transplantation surgery at Ospedale Niguarda (Milan), and Director of Niguarda Transplant Center. Prof. De Carlis is Professor of Surgery at University of Milan and at University of Pavia, Professor of Hepato-bilio-pancreatic Surgery at Henry Bismuth Institute; moreover he is member of the Ethics Committee at Niguarda Hospital (Milan), and President of the FATE Foundation for liver transplant activity.

Professor De Carlis was visiting Fellow in Transplant Surgery Center at the University of Pittsburgh (USA), and visiting Professor at the Department of Surgery of the University of Tokio (Jp), and at the Division of Transplantation at the University of Kyoto (Jp). As Director of Niguarda Transplant Center, Prof. De Carlis performed as First Operator more than 4000 surgical intervention in the field of epato-bilio-pancreatic surgery and general surgery, thoracic and vascular surgery, as well as in the field of hepatic, kidney and combined pancreatic-kidney transplantation. Starting from 2001 he successfully introduced in Italy the first adult living donor liver transplantation program.

Prof. De Carlis is member of the Italian Surgery Society (SIC), Italian Organ Transplantation Society (SITO), International Association Of Surgeons, Gynecologists and Obstetrics (IASGO), Romanian Association for the Study of the Liver (RASL), and of the European Society for Organ Transplantation (ESOT).

Dr. Luca Belli

Dr. Belli is the Chief of Department of Hepatology and Gastroenterology, and the Responsible of “Liver Unit”, Niguarda Hospital, Milan. Dr Belli participated at the development of the Liver Transplant Program of the Niguarda Hospital of Milan with more than 1600 transplants performed so far.

His scientific and professional interests extend to 1) recurrent hepatitis after liver transplantation 2) immunogenetics of hepatitis C 3) hepato-oncology (new anti-angiogenetic drugs for HCC)

Prof. Vincenzo Mazzaferro

Prof. Mazzaferro is the Chairman of the Department of Surgery and the Director Gastrointestinal, HPB Surgery and Liver Transplantation Unit of the National Cancer Institute (Milan). Moreover he is the Director of Training Center in Hepato-Pancreato-Biliary (HPB) diseases at the University of Milan and the Italian Association of Hospital Surgeons. Prof. Mazzaferro is Member of the Editorial Board of several Journals, among others Liver transplantation, Hepatology, Lancet Oncology, Annals of Surgery, and Associated Editor of Journal of Hepatology. Funding member of ILCA (International Liver Cancer Association). Member of EASL, AASLD, ASCO. From 2013 he is Coordinator of the ENET (European NeuroEndocrine Tumors) Center of Excellence, and Hepato-Oncology at INT (Milan). His field of expertise are the treatment of of HPB malignancies and related conditions, including liver transplantation, resection, ablation, combined loco-regional and systemic therapies. Prof. Mazzaferro participates to several clinical research projects within international partnerships.

 

Prof. Luca Gianotti

Prof. Gianotti is Associate Professor of Surgery, Milano-Bicocca University, San Gerardo Hospital, Monza.

He was Chair and coordinator for the guidelines of European Society of Parenteral and Enteral Nutrition on parenteral nutrition in pancreatic diseases (2008), Chair and coordinator of the italian multicenter trial on: “glutamine supplementation in elective surgery” (2007-2010); he actually is Chair and coordinator of the Italian multicenter trial on: “Preoperative carbohydrate loading in elective surgery”, vice president of SINPE, Segretary General of SIS-E, and Member of the Ethical Committee of Monza-Brianza.

The major goal of his clinical research is to study the immunometabolic response to surgical injury, the alteration of the homeostasis and their potential impact on postoperative outcome with particular emphasis on infections. Prof. Gianotti studied the modulation of the involved mechanisms through the administration of nutritional substrates with the ability of affect the inflammatory and immune response with the final aim of decreasing surgery-related complications. More recently, he has been involved in the “enhanced recovery after surgery” (ERAS) program to optimized the postoperative course of major gastric and HBP surgery.

Prof. Gianotti have performed more than 2700 surgical procedure as chief surgeon.

 

Prof. Fabio Uggeri

Professor Uggeri is Assistant Professor in General Surgery, University of Milan-Bicocca, Member and Professor of educational council in graduate schools of General Surgery, Surgery of Digestive System, Otolaringology, Vascular Surgery, Gynecology and Obstetrics, Geriatrics and Oncology. Responsible for the module of Clinical Cardio-Pulmonary in Degree in Physical Therapy and of Pathophysiology and Surgical Gynecology in Degree course in Midwifery of University of Milan-Bicocca.

His surgical activity is focused on hepato-biliary surgery, pancreatic surgery and advanced laparoscopic surgery. He developed skill in both open and laparoscopic liver resection for HCC and liver metastases and also in pancreatic surgery (open, laparoscopic and robotic). Professor Uggeri is also focused on development in new technology for the surgery of the liver, pancreas and spleen. In the last ten years the team allowed the laparoscopic approach to the splenic surgery to became the gold standard of splenic disorder with more than 200 procedures, being one of the Europe leading group. The group of Prof. Uggeri introduced the use of some new devices like ( Ligasure, Vessel sealing system) in liver resection and some hemostartic device like Tachosil for the treatment of pancreatic stump after pancreatic surgery. The improvement of the detection of cystic lesions of the pancreas allow us to define protocol to detected the malignancy of these lesions. The group studied the intracystic fluid according to DNA quantification, K-ras 2 mutations, inattivation of diTP53, DPC4/SMAD4/MADH4, STK1/LKB1, P13KCA, Beta catenin gene mutations, allelic embalance. Since 10 years the group study the immunodulation with IL-2r in patients with pancreatic, gastric and colo-rectal cancer who underwent to radical surgery.

Professor Uggeri is a Member of the Surgeon Italian Society ( SIC), the Italian Society of University Surgeon ( SICU), and of the Oncology Surgical Italian Society ( SICO).

 

Prof. Massimo Puoti

Prof. Puoti is Chief Division of Infectious Diseases AO Ospedale Niguarda Ca’ Granda, Milano; he has focused his research on three key areas 1) Viral Hepatitis 2) HIV infection and HIV-Hepatitis co-infection 3) Infections in the compromised patients. In the field of viral hepatitis Prof. Puoti collaborated from 1989 with experimental studies aimed to identify assays for measuring HCV and HDV RNA and HCV genotypes and we have used these tools to define epidemiology and natural history of hepatitis C and Delta in Italy in patients with and without HIV coinfection. In the same year his group started, with a structured collaboration with the General Practitioners of Brescia province, a hepatitis outpatient clinic that in 2005 included 3000 patients with HCV monoinfection ( 1000/3000 treated at least once with interferon based therapies), 1500 with HBV monoinfection or HBV-HDV coinfection (950 treated or on treatment with Interferon and/or nucleoside analogues) and 1500 with HIV infection and hepatitis viruses coinfection. During these years he has take part to several national and international cohort studies and registrative studies with anti HCV drugs: interferon and/or ribavirina based therapies and in the last year Telaprevir and Boceprevir. From 2010 as the director of the division of Infectious Diseases of the Hospital AO Niguarda Ca’ Granda Prof Puoti have been involved in most of the seminal registrative studies on anti HCV directly acting antivirals inckuding also HIV infected patients. Due to this large clinical expertise Prof Puoti was involved as a member of the writing committee in several national, European and International guidelines on the management of viral hepatitis with or without HIV coinfection.

In the last 5 years, directing the Dept of Infectious Diseases of the Niguarda Hospital (the largest Hospital in Milano, Italy) Prof Puoti has collaborated to develop a program of solid organ transplantation in persons living with HIV. As an expert in the field of infections in the compromised host he has developed a consistent clinical and reasearch activity as an Infectious Diseases consultant in the two Hospital where he worked both with more than 1200 inpatients beds taking part to several programs of prevention and management of infections in compromised patients ( haematological patients, solid organ transplant recipients, patients in intensive care units) and in patients with decompensated liver diseases. His H index is 35 by Scopus (1996-2014) and 41 by Google

 

Prof. Pietro Invernizzi

e-mail: pietro.invernizzi@unimib.it

 

Prof. Donatella Barisani

e-mail: donatella.barisani@unimib.it

Prof. Donatella Barisani obtained her M.D. in 1990, Specialization in GI in 1994 and in Medical Genetics in 2000 (all from the University of Milan).

From 1992 to 1995 she was research fellow at the Gastrointestinal Division – Brigham and Womens’ Hospital, Harvard Medical School, Boston, MA, USA (Prof. J.L. Gollan) and at the Nutrition Department, Harvard School of Public Health, Boston, MA, USA (Prof. M. Wessling-Resnick), mainly focusing on iron transport in the liver. From 1995 to 2001 she worked at the Dept of Biology and Genetics of the University of Milan analyzing iron metabolism and the mechanisms regulating iron uptake in vitro and in vivo. From 2002 Assistant Professor and from 2010 Associate Professor in Applied Biology at the Faculty of Medicine, University of Milano Bicocca.

Prof. Barisani has an extensive experience in basic reasearch, ranging from transport studies in in vitro and animal models to biochemistry and molecular biology.

Her main research interest is to identify genes and pathways involved in the development of celiac disease, with a focus on gene expression regulation (in particular by miRNAs) and immunity.

She was a Fulbright visiting scientist, has published 49 papers in peer-review journals (about 1800 citations, H index =19, total IF about 320), has been a selected speaker in more than 30 international congresses, has served as a reviewer for several journals (including NEJM), and is a member of the Editorial Board of The American Journal of Physiology. She has various ongoing collaborations with European centers on celiac disease.

Giovannoni Roberto

Dr. Roberto Giovannoni

e-mail: roberto.giovannoni@unimib.it

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Dr. Antonio Ciaccio

Senior Attending Physician, Gastroenterology

ASST Monza, San Gerardo Hospital

 

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Dr. Chiara Viganò

Senior Attending Physician, Gastroenterology

ASST Monza, San Gerardo Hospital

 

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Prof. Guadalupe Garcia-Tsao, MD

 

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Prof. James Boyer, MD

Dr. James L. Boyer is the Ensign Professor of Medicine and Emeritus Director of the Liver Center at Yale University School of Medicine. He is a graduate of Haverford College (1958) and the Johns Hopkins University School of Medicine (1962). From 1982 until 1996 he directed a combined Digestive Disease Section in the Department of Medicine. He was the founding Director of the NIDDK funded Liver Center at Yale since 1984. and former Director of the NIEHS Center for Membrane Toxicity Studies at the Mt Desert Island Biological Laboratory in Salsbury Cove, ME where he was also Chairman of their Board of Trustees from 1995 to 2003 and again from 2011-2013. He is also past Chair, Board of Directors of the American Liver Foundation and a current member of Board of Mangers of Haverford College. Dr. Boyer has a broad interest in all aspects of basic and clinical hepatology. His laboratory’s major efforts have been the study of mechanisms of bile formation and cholestasis , currently supported by a MERIT award from NIDDK. He is a member of the AASLD, ASCI, AAP,APS and ACCA and past president of both the American and the International Association for the Study of Liver Disease. He is the recipient of Distinguished Achievement Awards from the AGA, AASLD and American Liver Foundation.
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Prof. Fred Gorelick, MD

After completing medical school and internal medicine training at the University of Missouri, Dr. Gorelick trained at Yale in Gastroenterology. After his clinical training, he began basic science training with Dr. James Jamieson at Yale. During that period he described calcium-calmodulin dependent protein kinase II and subsequently worked with Dr. Paul Greengard (Rockefeller University) to examine the enzyme’s mechanism of activation, a response critical to neuronal memory.

His later work has focused on the mechanisms of acute pancreatits and how digestive enzymes, such as trypsin, are activated within the pancreas during this disease. Dr. Gorelick sees patients with gastrointestinal diseases at the VAMC in West Haven, CT. He is also the Deputy Director for the Yale physician Scientist program and directs a year-long course for the group that links basic science to clinical disease. He laboratory at the VA studies the molecular mechanisms related to acute pancreatitis with a goal of developing tools that prevent or lessen disease.

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Prof. Michael Nathanson, MD, PhD

 

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Dr. Massimiliano Cadamuro, PhD
e-mail: massimiliano.cadamuro@celiver.org

Graduated in Biological Sciences with emphasis in Molecular Biology at the University of Padova (Italy). In the same institution he received his PhD degree at the School of Biology and Medicine of Regeneration, course of Gastroenterology and Hepatology. He had been visiting scientist at the Dep. of Morphology and Molecular Pathology of the Leuven University (Belgium), the Hormone and Metabolic Research Unit of the Université Catholique de Louvain, (Bruxelles, Belgium) and the Liver Center Laboratories of the Yale University (New Haven, USA). He currently is a member of the CeLiveR laboratory at the Ospedali Riuniti di Bergamo Italy). He’s a member of the Italian Association for the Study of the Liver (AISF).
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Dr. Romina Fiorotto, PhD
e-mail: romina.fiorotto@yale.edu

Graduated in Biological Sciences at the Universita’ degli Studi di Padova in 1999. She received her Ph.D. from the Universita’ degli Studi di Parma in 2005. In 2005 he received a scholarship from the Foundation for Research on Cystic Fibrosis. She has been Research Fellow at the Department of Surgical and Gastroenterological Sciences Universita’ di Padova “PG Cevese”. Currently she is Research Associate Scientist at Yale University, USA. She collaborated with the CeLiveR since its founding. Dr. Fiorotto and scientific studie focus on the pathophysiology of biliary epithelium with particular interest in liver regeneration and the study of genetic diseases like cystic fibrosis and Alagille syndrome and polycystic disease of the liver. She has broad esperience on several scientific methodologies ranging from molecular and cellular biology, histology, management of colonies of transgenic mice with the generation of different experimental models of liver injury, cell transplantation techniques. She is a member of the Italian Association for the Study of Liver (AISF).
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Dr. Carlo Spirlì, PhD
e-mail: carlo.spirli@yale.edu

Carlo Spirli’ graduated in Biological Sciences at the University of Padova in 1995. He received his Ph.D at the University of Parma in 2000. He did his post-doc training at the Department of Medical and Surgical Sciences of the University of Padova from 2000 to 2004. Researcher at the Ospedali Riuniti di Bergamo-CeLiveR from 2004 to 2005. Currently, Associate Research Scientist Yale University, USA. Member of scientific societies: Italian Association for the Study of Liver (AISF), American Gastroenterological Association (AGA) and of the American Association for the Study of Liver Diseases (AASLD). He is reviewer for scientific journals such as: Journal of Experimental Biology and Medicines, American Journal of Physiology, Natures Clinical Practice Gastroenterology and Hepatology, BMC Physiology, Digestive Liver Diseases and Gastroenterology Research and Practice.

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